Pharmacogenetics (PGx)


Pharmacogenetics (PGx)


A comprehensive health and wellness test (sometimes called pharmacogenomics) that examines how genes affect individual responses to medications. This helps doctors select the drugs and dosages best suited for each person.

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Understanding Pharmacogenetics (PGx)

With this once in a lifetime test, you'll be able to truly understand your body's response to medications. Take the guess work out - with this genetic test, feel empowered by the knowledge you gain and ensure you are prescribed medications that are best for you, without the fear of ineffective or fatal medications or dosages.

Pharmacogenetics (PGx) also referred to as Personalized Medicine looks at variations in genes for proteins that influence drug responses. Such proteins include several liver enzymes that convert medications into their active or inactive forms. Even small differences in the genetic sequences of these enzymes can have a big impact on a drug’s safety or effectiveness.

The four process areas in determining your personalized response to medicine.


  • Absorption usually refers to how a drug enters the bloodstream after a person takes a pill or uses an inhalant; intravenous injection circumvents absorption by putting a drug directly into the blood.


  • Distribution describes where the drug travels after absorption and how much of the drug reaches the target site. Many drugs, for example, cannot get past the blood-brain barrier.


  • Metabolism refers to how the drug gets broken down in the body, which can happen immediately by way of enzyme action in the stomach and sometimes involves end products with their own pharmacologic action.


  • Excretion describes how drugs leave the body, whether by urine, bile, or, in some cases, exhalation.

The Food and Drug Administration, which monitors the safety of all drugs in the United States, has included pharmacogenetics information on the labels of more than 150 medications. This information — which can cover dosage guidance, possible side effects or differences in effectiveness for people with certain genomic variations — can help doctors tailor their drug prescriptions for individual patients.

Currently, doctors base most their drug prescriptions on clinical factors, such as a patient’s age, weight, sex, and liver and kidney function.

For a small subset of drugs, researchers have identified genetic variations that influence how people respond. In these cases, doctors can use the pharmacogenetics information to select the best medication and identify people who need an unusually high or low dose.