True Blueprint Bundle


True Blueprint Bundle


The True Blueprint genetics test bundle is one of the most comprehensive genetic testing available. The bundle includes the following tests: Healthy Weight, Genetically Matched Diet, Pharmacogenetics (your body’s response to medications), Cancer, Cardiac and Carrier status. Also, enjoy a savings of 16% by ordering the full bundle vs. separate tests.

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Understanding the True Blueprint Genetic Tests

Genes are instructions, written in DNA, for building protein molecules. Different people can have different versions — slightly different DNA sequences — of the same gene. Some of these variations are common and some are rare. Some are relevant for health, such as those associated with a tendency to develop certain diseases.

Healthy Weight Personal Profile is a comprehensive health and wellness genetic test that provides a unique combination of information regarding nutrigenetics, medication response, and a number of common health conditions. Using a proprietary algorithm, this test also provides a genetically-matched diet allowing patients to make educated decisions to help achieve or maintain a healthy weight.

  • Eating Behaviors
  • Health
  • Medication
  • Exercise
  • Weight/Diet
  • Metabolic Factors
  • Nutrition

Genetically-Matched Diet: Learn your genetic diet type

  • Matching Diet
  • Response to Monosaturated Fats
  • Response to Polyunsaturated Fats
  • Omega-6 and Omega-3 Levels

Your Body and Weight: Discover how to lose weight faster

  • Metabolism
  • Obesity
  • Weight Loss-regain
  • Adiponectin Levels

Exercise: Find out if you’re built for endurance or strength

  • Aerobic Capacity (VO2max)
  • Endurance Training
  • Loss of Body Fat Response to Exercise
  • Muscle Power
  • Strength Training
  • Weight Loss Response to Exercise/BMI Response to Exercise
  • Achilles Tendinopathy
  • Blood Pressure Response to Exercise
  • HDL (Good) Cholesterol Response to Exercise
  • Insulin Sensitivity Response to Exercise

Nutritional Needs: Learn which vitamins you need to optimize

  • Folate – Folic Acid
  • Vitamin A
  • Vitamin B
  • Vitamin B2
  • Vitamin B6
  • Vitamin B12
  • Vitamin C
  • Vitamin D
  • Vitamin E

Metabolic: Learn how your diet affects your cholesterol

  • Decreased HDL Cholesterol
  • Elevated Blood Sugar
  • Elevated LDL Cholesterol
  • Elevated Triglycerides

Custom Diet: Custom diet guideline matches genetics with your ratio of calories from carbs, fats and proteins

Eating Behavior: Discover the genetics behind your eating habits

  • Eating Disinhibition
  • Snacking
  • Sweet Tooth
  • Food Desire
  • Satiety-Feeling Full
  • Hunger

Food Reactions: Learn how your body reacts to common foods

  • Alcohol Flush
  • Bitter Taste
  • Caffeine Metabolism
  • Lactose Intolerance
  • Sweet Taste

Cancer Status test examines 123 genes associated with potential risk for hereditary cancer syndrome. These panels include well-established genes, but also includes candidate genes that may have only been recently discovered or for which additional research is needed. The hereditary cancer tests maximize the chances of identifying pathogenic cancer susceptibility variants, while providing a comprehensive review of candidate genes to give you information you can use now and potentially in the future.

This test works by analyzing cell-free DNA (cfDNA). It detects the presence of specific genomic markers called circulating tumor DNA (ctDNA) in 9 cancer driver genes. This test analyzes 96 tumor markers in 9 cancer driver genes.

Cancer Types

  • Breast
  • Ovarian
  • Nervous System/Brain
  • Colorectal
  • Melanoma
  • Endometrial
  • Pancreas
  • Fanconi Anemia
  • Prostate
  • Gastric
  • Hematologic Malignancy
  • Thyroid
  • Sarcoma
  • Renal/Urinary
  • Paraganglioma-Pheochromaticytoma

Cardiac Status helps identify 23 traits associated with an increased risk of developing certain heart-related health conditions, and provides insight into your potential responses to commonly prescribed medications, so your physician can develop a more personalized treatment for you.

  • Learn if you have specific genetic variants associated with an increased risk of developing certain heart-related heart conditions.
  • Learn how you are likely to respond to eight classes of commonly prescribed medications that are used to treat heart-related conditions.
  • Learn which heart-related medications should be used with caution and may cause adverse side effects.

Carrier Status allows patients to gain knowledge on their risks of passing inheritable genetic diseases to their children or future children. A more comprehensive assessment can be obtained if both parents are tested.

  • Screens for more than 120 recessive genetic diseases.
  • Supported by rigorous science using clinically-relevant, well-validated markers and assays.
  • Enables physicians to offer calculated guidance on pre and postnatal health.

Understanding Carrier Status
Each person has two copies of the genetic materials, one copy inherited from each parent. Many genetic diseases are recessive, meaning the disease is caused by inheriting a mutation at the same DNA location from both parents. If a parent carries a mutation in one of the two copies of the DNA, he/she is a carrier of the genetic disease.

A carrier has a 50% chance of passing the same mutation to the child. If both parents are carriers, the child will have a 25% chance of inheriting both copies of the mutation, thus leading to the development of the genetic disease. Some inherited diseases are more common in certain ethnic groups and in people with a family history of genetic disorders.

Pharmacogenetics (PGx) also referred to as Personalized Medicine looks at variations in genes for proteins that influence drug responses. Such proteins include several liver enzymes that convert medications into their active or inactive forms. Even small differences in the genetic sequences of these enzymes can have a big impact on a drug’s safety or effectiveness.

The four process areas in determining your personalized response to medicine.


  • Absorption usually refers to how a drug enters the bloodstream after a person takes a pill or uses an inhalant; intravenous injection circumvents absorption by putting a drug directly into the blood.


  • Distribution describes where the drug travels after absorption and how much of the drug reaches the target site. Many drugs, for example, cannot get past the blood-brain barrier.


  • Metabolism refers to how the drug gets broken down in the body, which can happen immediately by way of enzyme action in the stomach and sometimes involves end products with their own pharmacologic action.


  • Excretion describes how drugs leave the body, whether by urine, bile, or, in some cases, exhalation.

The Food and Drug Administration, which monitors the safety of all drugs in the United States, has included pharmacogenetics information on the labels of more than 150 medications. This information — which can cover dosage guidance, possible side effects or differences in effectiveness for people with certain genomic variations — can help doctors tailor their drug prescriptions for individual patients.

Currently, doctors base most their drug prescriptions on clinical factors, such as a patient’s age, weight, sex, and liver and kidney function.

For a small subset of drugs, researchers have identified genetic variations that influence how people respond. In these cases, doctors can use the pharmacogenetics information to select the best medication and identify people who need an unusually high or low dose.